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HYALURONIC ACID FILLERS (Juvederm, Restylane, Perlane)

  • Hyaluronic acid is naturally found in all living beings, it is broken down and replaced within 1-2 days
  • The role of Hyaluronic Acid in skin is to deliver nutrients, hydrate the skin by holding in water, and to act as a cushioning agent.
  • But as you age the amount of Hyaluronic Acid reduces in your skin. The lack of Hyaluronic Acid causes your skin to lose structure and volume, creating unwanted facial wrinkles and folds around your nose and mouth.
  • Dermal fillers effectively replace the Hyaluronic Acid of your skin, bringing back its volume and smoothening away facial wrinkles and folds.
  • They temporarily add volume to the facial tissue and give the appearance of a smoother surface.
  • Manufacturers prolong longevity of hyaluronic acid fillers by cross-linkage.
  • They last between 6-9 months
  • Hyaluronic acid fillers are the only fillers that can be immediately reversed by injection of an enzyme hyaluronidase.
  • In 2003 the FDA approved Hyaluronic Acid injections for filling soft tissue defects such as facial wrinkles.
Different Hyaluronic acid (HA) fillers differ in
  • Degree of crosslinking
Cross-linking is the only way to achieve durability with HA product. Uncross-linked HA would last several hours to one day, whereas cross-linked HA lasts for months.
Juvederm is more heavily cross-linked than Restylane
  • Concentration
Juvederm has highest concentration (24mg/cc). Restylane (20mg/cc)
  • Gel hardness (G prime)
Perlane has the highest, followed by Restylane, Juvederm
  • Viscosity
Force required to push a product through a syringe, directly proportional to the G prime
Restylane has higher viscosity than Juvederm